Flu antibody's 'one-handed grab' may boost effort toward universal vaccine
Scientists from The Scripps Research Institute and Sea Lane Biotechnologies have solved the co-crystal structure of a human antibody that can neutralize influenza viruses in a unique way. The antibody...
View ArticleNew chemistry technique reproduces nature's elusive complexity
(Phys.org)—Scientists at The Scripps Research Institute have shown how to synthesize in the laboratory an important set of natural compounds known as terpenes. The largest class of chemicals made by...
View ArticleScientists devise screening method to aid RNA drug development research
(Phys.org)—Scientists from the Florida campus of The Scripps Research Institute (TSRI) have developed a new method of screening more than three million combinations of interactions between RNA and...
View ArticleBacterial genes energy-sensing switch discovery could have broad implications
Biochemists at The Scripps Research Institute (TSRI) have discovered a genetic sequence that can alter its host gene's activity in response to cellular energy levels. The scientists have found this...
View ArticleNew inhibitors of elusive enzymes promise to be valuable scientific tools
(Phys.org)—Scientists at The Scripps Research Institute (TSRI) have discovered the first selective inhibitors of an important set of enzymes. The new inhibitors, and chemical probes based on them, now...
View ArticleScientists show protein-making machinery can switch gears with a small...
For the past several years, Min Guo, an assistant professor at The Scripps Research Institute, has focused on the intricate actions of an ancient family of catalytic enzymes that play a key role in...
View ArticleNew powerful toolkit accelerates creation of potential new drugs
Scientists at The Scripps Research Institute (TSRI) have invented a set of chemical tools that is radically simplifying the creation of potential new drug compounds.
View ArticleScientists discover how two proteins help keep cells healthy
Scientists at The Scripps Research Institute (TSRI) have determined how two proteins help create organelles, or specialized subunits within a cell, that play a vital role in maintaining cell health....
View ArticleScientists develop new compound that reverses fatty liver disease
(Phys.org)—Scientists from the Florida campus of The Scripps Research Institute (TSRI) have developed the first synthetic compound that can reverse the effects of a serious metabolic condition known as...
View ArticleScientists create new approach to destroy disease-associated RNAs in cells
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have developed a new approach to alter the function of RNA in living cells by designing molecules that recognize and disable...
View ArticleChinese medicine yields secrets: Atomic mechanism of 2-headed molecule...
The mysterious inner workings of Chang Shan—a Chinese herbal medicine used for thousands of years to treat fevers associated with malaria—have been uncovered thanks to a high-resolution structure...
View ArticleA feat in synthetic chemistry: Steroids that only nature could make on a...
Scientists at The Scripps Research Institute (TSRI) have achieved a feat in synthetic chemistry by inventing a scalable method to make complex natural compounds known as "polyhydroxylated steroids."...
View ArticleNew study defines the long-sought structure of a protein necessary for...
Scientists know that cells in all higher organisms cells need to bind to each other for the development, architecture, maintenance and function of tissues. Mysteries have remained, however, about...
View ArticleChemists devise inexpensive, benchtop method for marking and selecting cells
Chemists at The Scripps Research Institute (TSRI) have found an easier way to perform one of the most fundamental tasks in molecular biology. Their new method allows scientists to add a marker to...
View ArticleScientists discover structure of protein essential for quality control, nerve...
(Phys.org)—Using an innovative approach, scientists at The Scripps Research Institute (TSRI) have determined the structure of Ltn1, a recently discovered "quality-control" protein that is found in the...
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